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As advertising-funded site owners, I’m going to argue the first and last are irrelevant for us. The freeloaders you can’t deal with regardless (see: file sharing), and those that block from a technical standpoint are going to be extremely difficult to please, for the simple reason that we’ve hammered it into their subconscious for years that advertising consists of invasive content. Even if Ars, for example, promises no popups, no Flash, no audio, and no interstitials, users just don’t think that way. Ads change over time. This page view may be different than the next. It’s easy to block, so might as well block than risk having something jump out at you down the line.
Instead, targeting is a far better option. This includes typical content relevancy (a la AdSense), but it also includes better, high-brow ads. It’s the same reason people watch the Super Bowl commercials instead of flipping away: ads are just better then. Far easier to watch. The problem, of course, is that these two areas are extremely hard to make work.
